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Treatment - management of the fracture wound

Methicillin-sensitive S. aureus (MSSA) is still the most likely infecting organism in most areas. Institutionalized patients have a higher risk of methicillin-resistant S. aureus (MRSA), in which cases vancomycin may be advisable.

Coverage with antibiotics active against gram-negative microorganisms is wise for hospital-acquired infections.
All of the above should be considered provisional treatment until culture results become available.