Definitive antibiotic treatment
Once culture results and sensitivities are known, choose the optimal antibiotic for the infection, in consultation with an infectious-disease specialist. Remember that antibiotics are but an adjunct to adequate surgical clearance, and recognize that an infection that does not respond will need repeat surgical exploration and clearance.
If laboratory services are limited, then the choice of antibiotics is determined by the most appropriate available for the most likely organisms.
Prolonged intravenous antibiotics (e.g., six weeks), the use of combinations of drugs, and continued oral medication after initial intravenous therapy may be necessary.