Filling this dead space is an important part of wound management. Alternative treatment strategies include the use of antibiotic beads, or other temporary space fillers (calcium sulphate, bone cement, etc.). The wound itself should be covered to avoid desiccation, or secondary contamination. This can be done with an impermeable dressing (adherent plastic), or with vacuum-assisted closure (VAC), as illustrated. The latter, by applying suction, reduces dead space volume in pliable tissues.