As in all open fracture injuries, the patient must receive anti-tetanus prophylaxis and appropriate antibiotic coverage. Antibiotics should be given intravenously as soon as possible.
Generally, all open fractures are treated with coverage for typical skin bacteria, often a 1st generation cephalosporin. Higher grade open fracture wounds will require additional coverage for gram-negative organisms. With soil or barnyard injuries, high-dose penicillin should be added to cover possible clostridial infection (gas gangrene).