Systemic antibiotics are a critical part of open fracture wound management. Their choice and duration will depend upon several factors including severity of the wound, patient comorbidities, contamination etc.
Antibiotics may also be applied locally to deliver high concentrations directly to the wound site itself.
Methylmethacrylate impregnated with heat-stable antibiotics is shaped into small beads to increase their surface area and to optimize antibiotic elution. After placement onto a suture, the beads are placed within the wound to fill the dead space. The wound is then closed primarily or covered with an adhesive drape. Generally, beads are left in for at least 2-5 days.